The OPP, EMS and the Ministry of Environment were called to a collision near Matheson which closed both lanes of Highway 11.
Both lanes have since reopened following the collision.
Police say the head on collision was between two transport trucks where one driver was declared dead at the scene and the other taken to hospital.
The Ministry of Environment has been at the scene to clean up and aid in the investigation.
The collision closed Highway 11 in both directions near Val Gagne.